HDAC-IN-58

HDAC-IN-58 is a HDAC inhibitor. HDAC-IN-58 has HDAC6-specific inhibition activity with an IC50 value of 2.06 nM. HDAC-IN-58 can be used for the research of chronic diseases, including neurodegenerative and psychiatric conditions[1].

Product Specifications

CAS Number

[2071224-39-8]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hdac-in-58.html

Solubility

10 mM in DMSO

Smiles

CS(=O)(N(C1=CC=CC(Cl)=C1)CC2=NC=C(C3=NN=C(C(F)F)O3)C=C2)=O

Molecular Formula

C16H13ClF2N4O3S

Molecular Weight

414.81

References & Citations

[1]Motlová L, et al. Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6) . ACS Chem Biol. 2023 Jul 21;18 (7) :1594-1610.