AD186

AD186 is a potent and selective S1R agonist with Kis of 2.7, 27 nM for S1R and S2R, respectively. AD186 fully reverses the antiallodynic effect of BD-1063 (HY-18101A) [1].

Product Specifications

UNSPSC

12352005

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ad186.html

Solubility

10 mM in DMSO

Smiles

N1(CCC2=CC=CC=C2)CC3(CCN(CC4=CC=CC=C4)CC3)C1

Molecular Formula

C22H28N2

Molecular Weight

320.47

References & Citations

[1]Dichiara M, et al. Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands. ACS Chem Neurosci. 2023 May 17;14 (10) :1845-1858.