Anti-osteoporosis agent-3

Anti-osteoporosis agent-3 (Compound 11), a PMSA derivative, is an anti-osteoporosis agent. Anti-osteoporosis agent-3 inhibits osteoclastogenesis with an IC50 value of 322.9 nM in vitro. Anti-osteoporosis agent-3 also blocks the formation of F-action belts and bone resorption[1].

Product Specifications

CAS Number

[2944463-16-3]

UNSPSC

12352005

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-osteoporosis-agent-3.html

Solubility

10 mM in DMSO

Smiles

O=C(OC)C1=CC(NCC(NC2=C(C=CC=C2)SC3=CC=CC=C3)=O)=CC=C1

Molecular Formula

C22H20N2O3S

Molecular Weight

392.47

References & Citations

[1]Chen Z, et al. Discovery of PMSA Derivative 11 as a Novel Lead Compound for Therapeutic Treatment of Osteoporosis In Vitro and In Vivo. J Med Chem. 2023 May 25;66 (10) :6766-6781.