TS-IN-2
TS-IN-2 (compound 17) is a thymidylate synthase (TS) inhibitor with an IC50 of 0.81 μM. TS-IN-2 induces cancer cell apoptosis and cell cycle arrest in S phase, and also inhibit DNA synthesis, resulting in DNA damage[1].
Product Specifications
CAS Number
2945983-00-4
UNSPSC
12352005
Target
Thymidylate Synthase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ts-in-2.html
Solubility
10 mM in DMSO
Smiles
S=C1OC(COC2=CC=C(CC=C)C=C2OC)=NN1CN3CCOCC3
Molecular Formula
C18H23N3O4S
Molecular Weight
377.46
References & Citations
[1]Syed Nazreen, et al. New Natural Eugenol Derivatives as Antiproliferative Agents: Synthesis, Biological Evaluation, and Computational Studies. ACS Omega. 2023 May 15;8 (21) :18811-18822.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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