ERRγ inverse agonist 2
ERRγ inverse agonist 2 (compound 19) is a potent and selective ERRγ inverse agonist with a Kd value of 6.5 μM. ERRγ inverse agonist 2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ inverse agonist 2 has antimicrobial, anti-coagulant and antidiabetic activities[1].
Product Specifications
CAS Number
324022-01-7
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/errγ-inverse-agonist-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN(C2=CC=CC=C2)N=C1C3=CC=CC=C3)NC4=CC(N)=CC(OC5=CC=CN=C5)=C4
Molecular Formula
C27H21N5O2
Molecular Weight
447.49
References & Citations
[1]Yang SH, et, al. Structure-based discovery of pyrazolamides as novel ERRγ inverse agonists. Eur J Med Chem. 2023 Mar 15;250:115174.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERRγ
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