MTHFD2-IN-2
MTHFD2-IN-2 (compound 13) is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor[1].
Product Specifications
UNSPSC
12352005
Target
Methylenetetrahydrofolate Dehydrogenase (MTHFD)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mthfd2-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=CC=C(C(N2CCC3=C(C2)C(OC4=C3C=CC=C4)=O)=O)C=C1C5CN=NN5
Molecular Formula
C22H18N4O5
Molecular Weight
418.40
References & Citations
[1]Jha V, et al. Binding Analysis and Structure-Based Design of Tricyclic Coumarin-Derived MTHFD2 Inhibitors as Anticancer Agents: Insights from Computational Modeling. ACS Omega. 2023 Apr 12;8 (16) :14440-14458.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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