Anti-inflammatory agent 41

Anti-inflammatory agent 41 (13a) significantly inhibit lipopolysaccharide (LPS) -induced expression of the proinflammatory cytokines IL-6 and TNF-α on J774A.1, THP-1 and LX-2 cells, and inhibits the activation of the NF-κB pathway[1].

Product Specifications

CAS Number

[2896204-90-1]

UNSPSC

12352005

Target

Interleukin Related; NF-κB; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-41.html

Solubility

10 mM in DMSO

Smiles

COC1=CC2=C(C(OC3=CC=C(C=C3)NC(C4=CN(C5=CC=CC=C5C4=O)C6=CC=CC=C6)=O)=CC=N2)C=C1OC

Molecular Formula

C33H25N3O5

Molecular Weight

543.57

References & Citations

[1]Jun Yang, et al. Discovery of 4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide derivatives as novel anti-inflammatory agents for the treatment of acute lung injury and sepsis. Eur J Med Chem. 2023 Mar 5;249:115144.