AcrB-IN-2

AcrB-IN-2 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. AcrB-IN-22 inhibits Nile Red (a known substrate of AcrB) efflux.AcrB-IN-2 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model[1].

Product Specifications

CAS Number

[2890177-90-7]

UNSPSC

12352005

Target

Bacterial; Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/acrb-in-2.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(C=C1)OCCCOC2=CC=CC3=C2C=C(C4=C3OC(C)(CC4)C)C(N5CCOCC5)=O

Molecular Formula

C30H35NO6

Molecular Weight

505.60

References & Citations

[1]Guo T, et al. Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance. Eur J Med Chem. 2023 Mar 5;249:115148.