AcrB-IN-2
AcrB-IN-2 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. AcrB-IN-22 inhibits Nile Red (a known substrate of AcrB) efflux.AcrB-IN-2 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model[1].
Product Specifications
CAS Number
2890177-90-7
UNSPSC
12352005
Target
Bacterial; Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/acrb-in-2.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)OCCCOC2=CC=CC3=C2C=C(C4=C3OC(C)(CC4)C)C(N5CCOCC5)=O
Molecular Formula
C30H35NO6
Molecular Weight
505.60
References & Citations
[1]Guo T, et al. Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance. Eur J Med Chem. 2023 Mar 5;249:115148.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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