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TGR5 agonist 2

TGR5 agonist 2 (compound 19) is a potent TGR5 agonist with an EC50 value of 0.27 µM[1].

Product Specifications

UNSPSC

12352211

Target

G protein-coupled Bile Acid Receptor 1

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tgr5-agonist-2.html

Solubility

10 mM in DMSO

Smiles

[H][C@]12C[C@H]([C@@]3([C@]([H])([C@@H](CCCC(NCCS(=O)(O[Na])=O)=O)C)CC[C@]3([C@@]1([C@@H]([C@@H]([C@@]4(C[C@@H](CC[C@@]42C)O)[H])CC)O)[H])[H])[H])C

Molecular Formula

C29H50NNaO6S

Molecular Weight

563.77

References & Citations

[1]Luxenburger A, et al. The discovery of 12β-methyl-17-epi-18-nor-bile acids as potent and selective TGR5 agonists. Eur J Med Chem. 2023 Mar 15;250:115143.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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