Bromodomain IN-2
Bromodomain IN-2 is a pan bromodomain (BD) inhibitor with KD values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4 (1), CBP, BRPF1B, BRD7, BRD9, BRDT (1), CECR2 respectively. Bromodomain IN-2 shows antiproliferative activity[1].
Product Specifications
CAS Number
2445335-77-1
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bromodomain-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C)NC(C3=C(Cl)C=CC(N)=C3)=C2CCCC1
Molecular Formula
C16H17ClN2O
Molecular Weight
288.77
References & Citations
[1]Warstat R, et al. A novel pan-selective bromodomain inhibitor for epigenetic drug design. Eur J Med Chem. 2023 Mar 5;249:115139.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; BRD7; BRD9; BRDT; BRPF1
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