Antibacterial agent 140 (chloride)

Antibacterial agent 140 chloride is a promising antibacterial agent. Antibacterial agent 140 chloride is also the first Ru-based AIEgen photosensitizer for simultaneous dual applications of Gram-positive bacteria (G+) detection and treatment. Antibacterial agent 140 chloride uniquely selective discriminates and efficient exterminates Gram-positive bacteria (G+) from other bacteria due to its interaction with lipoteichoic acids (LTA). Antibacterial agent 140 chloride  also possessed robust antibacterial activity for G+ under light irradiation[1].

CC(C)(C1=CC=C(C=C1)N2C(C3=CC4=C(C5=C3C=CC=C5)C=CC=C4)=NC6=C2C7=C8C9=C6C=CC=[N]9[Ru]%10%11([N]8=CC=C7)([N]%12=C%13C(C=CC%14=CC=C[N]%11=C%14%13)=CC=C%12)([Ru+])[N]%15=C%16C(C=CC%17=CC=C[N]%10=C%17%16)=CC=C%15)C.[Cl-].[Cl-]

[1]Mengling Liu, et al. Specific discrimination and efficient elimination of gram-positive bacteria by an aggregation-induced emission-active ruthenium (II) photosensitizer. Eur J Med Chem. 2023 May 5;251:115249.