ML786 (dihydrochloride)
ML786 dihydrochloride is a potent and orally bioavailable Raf inhibitor, with IC50s of 2.1, 4.2, and 2.5 nM for V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 dihydrochloride also inhibits Abl-1, DDR2, EPHA2, KDR, and RET (IC50=[1].
Product Specifications
CAS Number
1237536-18-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Bcr-Abl; Discoidin Domain Receptor; Ephrin Receptor; Raf; RET; VEGFR
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml786-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(CC1)NC2=C1C(OC3=CC=C(CC[C@@H](NC(C4=CC(C(F)(F)F)=CC(C(C)(C)N)=C4)=O)C5)C5=C3)=CC=N2.Cl.Cl
Molecular Formula
C29H31Cl2F3N4O3
Molecular Weight
611.48
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Abl; DDR2; Raf; VEGFR2/KDR/Flk-1
Frequently Asked Questions
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