RGH-560

RGH-560 (compound 53) shows highly advanced α7 nAChR positive modulator properties and favorable physicochemical features. RGH-560 has robust procognitive in vivo potential. RGH-560 can be used to study Scopolamine (HY-N0296) -induced amnesia in mice[1].

Product Specifications

CAS Number

[2408799-43-7]

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rgh-560.html

Solubility

10 mM in DMSO

Smiles

CN1C=CC2=C1C=CC(CNC(N3CC4(CC(C(C=CC(F)=C5)=C5O4)=O)C3)=O)=C2

Molecular Formula

C22H20FN3O3

Molecular Weight

393.41

References & Citations

[1]Ledneczki I, et al. Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560) . Journal of Medicinal Chemistry. 2023 Nov.