Urease-IN-10
Urease-IN-10 (Conjugate 4) is a competitive Urease inhibitor, with an IC50 of 3.59±0.07 μM and a Ki of 7.45 μM. Urease-IN-10 is a conjugate consisting of Diclofenac and Sulfanilamide (HY-B0242). Diclofenac-sulfanilamide inhibits the Jack bean urease (JBU) in a competitive manner[1].
Product Specifications
CAS Number
1012205-70-7
UNSPSC
12352005
Target
Bacterial; Urease
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/urease-in-10.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(NC(CC2=CC=CC=C2NC3=C(Cl)C=CC=C3Cl)=O)C=C1)(N)=O
Molecular Formula
C20H17Cl2N3O3S
Molecular Weight
450.34
References & Citations
[1]Ahmad S, et al. Exploring the Potential of New Benzamide-Acetamide Pharmacophore Containing Sulfonamide as Urease Inhibitors: Structure–Activity Relationship, Kinetics Mechanism, and In Silico Studies. 2023 Nov 22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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