CYP4A11/CYP4F2-IN-2
CYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC50s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease[1].
Product Specifications
CAS Number
[2280834-99-1]
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cyp4a11-cyp4f2-in-2-1.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C(O)=O)OCCCCCCCOC1=CC=C(C2=CC=NN2)N=C1
Molecular Formula
C19H27N3O4
Molecular Weight
361.44
References & Citations
[1]Kawamura M et al. Introduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2[J]. Bioorganic & Medicinal Chemistry, 2023: 117505.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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