CYP4A11/CYP4F2-IN-2

CYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC50s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease[1].

Product Specifications

CAS Number

[2280834-99-1]

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cyp4a11-cyp4f2-in-2-1.html

Solubility

10 mM in DMSO

Smiles

CC(C)(C(O)=O)OCCCCCCCOC1=CC=C(C2=CC=NN2)N=C1

Molecular Formula

C19H27N3O4

Molecular Weight

361.44

References & Citations

[1]Kawamura M et al. Introduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2[J]. Bioorganic & Medicinal Chemistry, 2023: 117505.