PVD-06
PVD-06 is a selective PROTAC PTPN2 degrader with a DC50 of 217 nM (selectivity index >60-fold over PTP1B). PVD-06 induces PTPN2 degradation via a VHL-, ubiquitin, and proteasome-dependent pathway. PVD-06 can promote T cell activation and amplify IFN-γ-mediated anticancer activity. PVD-06 can be used to further investigate PTPN2 in diseases such as leukemia and melanoma[1]. (Pink: PTPN2 ligand , Black: linker (HY-B0236), Blue: VHL ligand (HY-112078) ).
Product Specifications
CAS Number
3032975-48-4
UNSPSC
12352005
Target
IFNAR; Phosphatase; PROTACs; STAT
Type
Reference compound
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; PROTAC; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pvd-06.html
Purity
98.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
Molecular Formula
C48H55F4N9O11S2
Molecular Weight
1074.13
References & Citations
[1]Hu L et al. Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader. J Med Chem. 2023 Nov 23;66 (22) :15269-15287.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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