SHP2-IN-23
SHP2-IN-23 (compound 30) is an orally active SHP2 inhibitor (IC50=38 nM) with excellent in vivo efficacy and pharmacokinetic profiles. SHP2-IN-23 inhibits ERK phosphorylation with IC50=5 nM[1].
Product Specifications
CAS Number
2415989-91-0
UNSPSC
12352005
Target
ERK; SHP2
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp2-in-23.html
Solubility
10 mM in DMSO
Smiles
N[C@H]1C2(CCN(C3=NC4=C(N=C(C=C4)SC5=CC=NC(N)=C5Cl)N=C3)CC2)CC6=NC=CC=C61
Molecular Formula
C24H23ClN8S
Molecular Weight
491.01
References & Citations
[1]Elsayed M S A et al. Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors[J]. ACS Medicinal Chemistry Letters, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
KN416141 1 Kit
Dynein intermediate chain 2 (DNAI2) Human Gene Knockout Kit (CRISPR)
Sign In for Pricing
View Details