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ICMT-IN-53

ICMT-IN-53 (compound 12) is an ICMT inhibitor (IC50=0.96 μM) with PAMPA permeability and antiproliferative activity. ICMT-IN-53 inhibits the proliferation of MDA-MB-231 and PC3 with IC50s of 5.14 μM and 5.88 μM, respectively[1].

Product Specifications

CAS Number

1443253-17-5

UNSPSC

12352005

Target

ICMT

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/icmt-in-53.html

Solubility

10 mM in DMSO

Smiles

FC1=C(C=CN=C1)C2=CC=C(N(CCCCCCCC)C=C3CN(CC)CC)C3=C2

Molecular Formula

C26H36FN3

Molecular Weight

409.58

References & Citations

[1]Ramanujulu PM, et al. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt) . Eur J Med Chem. 2013 May;63:378-86.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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