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β2AR agonist 2

β2AR agonist 2 (compound 8a) is a β2 -Adrenergic receptor (β2AR) agonist. β2AR agonist 2 is a saturated nitrogen ring compound containing 4- to 7-membered heterocycle. β2AR agonist 2 has a chiral structure (the -R form) by carrying carbon containing the essential hydroxyl, thereby enhancing cellular glucose uptake (GU) activity and significantly stimulating glucose uptake by skeletal muscle cells. β2AR agonist 2 can be used in the study of Type 2 Diabetes (T2D) [1].

Product Specifications

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/β2ar-agonist-2.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=CC([C@@H](O)[C@@]2([H])C[C@@H](CCC)N2)=C1

Molecular Formula

C13H18FNO

Molecular Weight

223.29

References & Citations

[1]Jaunsleine K, et al. Development of novel β2-adrenergic receptor agonists for the stimulation of glucose uptake - The importance of chirality and ring size of cyclic amines. Bioorg Med Chem Lett. 2023 Nov 13:129562.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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