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HDAC4-IN-1

HDAC4-IN-1 (compound 1a) is a class IIa HDACI inhibitor (IC50=0.077 μM) . HDAC4-IN-1 can enhance Caspase-induced Apoptosis. HDAC4-IN-1 has anticancer activity. HDAC4-IN-1 can be used in the research of drug combination against cancer[1].

Product Specifications

CAS Number

1418293-39-6

UNSPSC

12352005

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac4-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCN(CC)CC)C1=CC=C(C2=NOC(C(F)(F)F)=N2)C=C1

Molecular Formula

C16H19F3N4O2

Molecular Weight

356.34

References & Citations

[1]Asfaha Y, et al. 5- (Trifluoromethyl) -1,2,4-oxadiazole (TFMO) -based highly selective class IIa HDAC inhibitors exhibit synergistic anticancer activity in combination with bortezomib. Eur J Med Chem. 2023 Nov 10;263:115907.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC2; HDAC4; HDAC6; HDAC8

Frequently Asked Questions

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