AKT inhibitor IV
Akt inhibitor-IV (AKTIV) acts as a PI3K-Akt inhibitor at the E isomer (HY-14971), with potent cytotoxicity[1].
Product Specifications
CAS Number
[681281-88-9]
Product Name Alternative
AKTIV
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Akt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akt-inhibitor-iv.html
Purity
99.40
Solubility
10 mM in DMSO
Smiles
CN(/C=C/C1=[N+](C2=CC=CC=C2)C3=CC=C(C4=NC5=CC=CC=C5S4)C=C3N1CC)C6=CC=CC=C6.[I-]
Molecular Formula
C31H27IN4S
Molecular Weight
614.54
Precautions
H315, H319, H335
References & Citations
[1]Changkun Hu, et al. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur J Med Chem. 2010 Feb;45 (2) :705-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Curated Selection
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