Antitumor agent-123
Antitumor agent-123 (Copmound 4d) effectively inhibits multiple kinase targets with anti-cancer effects, including JAK2, JAK3, HDAC1 and HDAC6, with IC50 values of 34.6 and 2.6 μM for JAK2 and JAK3, respectively. Antitumor agent-123 exhibits moderate activity in solid tumor models[1].
Product Specifications
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
HDAC; JAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-123.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(NC2=C3C(N(CC4=CC=C(C(NO)=O)C=C4)C=N3)=NC=N2)=CC=C1F
Molecular Formula
C19H14ClFN6O2
Molecular Weight
412.80
References & Citations
[1]Waitman KB, et al. HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents. Eur J Med Chem. 2023 Nov 10;263:115935.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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