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MEY-003

MEY-003 is an Autotaxin (ATX) inhibitor with EC50s of 460 nM and 1.09 μM for hATX-β and hATX-ɣ (analysis with LPC18:1) . MEY-003 behaves as a non-competitive inhibitor with K iof 432 nM. MEY-003 can be used for targeted ATX-related disease research [1].

Product Specifications

CAS Number

3047891-88-0

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mey-003.html

Solubility

10 mM in DMSO

Smiles

OC1=C2C(OC(C3=CN(CCCCC)C4=C3C=CC=C4)=CC2=O)=CC(O)=C1

Molecular Formula

C22H21NO4

Molecular Weight

363.41

References & Citations

[1]Eymery M C, et al. Discovery of potent chromone-based autotaxin inhibitors inspired by cannabinoids [J]. European Journal of Medicinal Chemistry, 2023: 115944.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Autotaxin

Frequently Asked Questions

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