MEY-003
MEY-003 is an Autotaxin (ATX) inhibitor with EC50s of 460 nM and 1.09 μM for hATX-β and hATX-ɣ (analysis with LPC18:1) . MEY-003 behaves as a non-competitive inhibitor with K iof 432 nM. MEY-003 can be used for targeted ATX-related disease research [1].
Product Specifications
CAS Number
3047891-88-0
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mey-003.html
Solubility
10 mM in DMSO
Smiles
OC1=C2C(OC(C3=CN(CCCCC)C4=C3C=CC=C4)=CC2=O)=CC(O)=C1
Molecular Formula
C22H21NO4
Molecular Weight
363.41
References & Citations
[1]Eymery M C, et al. Discovery of potent chromone-based autotaxin inhibitors inspired by cannabinoids [J]. European Journal of Medicinal Chemistry, 2023: 115944.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Autotaxin
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