R1-11
R1-11 is an indole ICMT inhibitor with an IC50 of 0.6 μM and has anticancer activity. R1-11 inhibits MDA-MB231 and PC3 cells with IC50s of 2.2 μM and 2.0 μM, respectively[1].
Product Specifications
UNSPSC
12352005
Target
ICMT
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r1-11.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCCN1C(CN(CC)CC)=CC2=CC(C3=CN=C(N)N=C3)=CC=C12
Molecular Formula
C25H37N5
Molecular Weight
407.59
References & Citations
[1]Yang WS et al. Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents. Amino Acids. 2017 Sep;49 (9) :1469-1485.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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