POP-3MB

POP-3MB (compound 1b) is an ICMT inhibitor (IC50: 2.5 μM) . POP-3MB changes the subcellular localization of K-Ras and inhibits Ras activation. POP-3MB also inhibits Erk phosphorylation[1].

Product Specifications

CAS Number

[1144114-27-1]

UNSPSC

12352005

Target

ERK; ICMT

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pop-3mb.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](CSC/C=C(C/C=C(C)/C)/CCC1=CC=C(C2=CC=CC=C2)C=C1)C(O)=O)C(C=CC=C3)=C3OC4=CC=CC=C4

Molecular Formula

C38H39NO4S

Molecular Weight

605.79

References & Citations

[1]Majmudar JD et al. Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization. Bioorg Med Chem. 2012 Jan 1;20 (1) :283-95.