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ICMT-IN-35

ICMT-IN-35 (compound 10n) is a FTPA-triazole compound and ICMT inhibitor (IC50=0.8 μM) . ICMT-IN-35 is taken up by mammalian cells and can prevent K-Ras membrane localization and induce K-Ras mislocalization. Furthermore, ICMT-IN-35 is selectively cytotoxic against ICMT+/+ MEF cells and has low micromolar activity (IC50=0.8 μM) against metastatic pancreatic cancer cell lines[1].

Product Specifications

UNSPSC

12352005

Target

ICMT

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/icmt-in-35.html

Solubility

10 mM in DMSO

Smiles

C/C(CCN(N=N1)C=C1CCC(C=C2)=CC=C2C3=CC=CC=C3)=C/SCCC(OC)=O

Molecular Formula

C25H29N3O2S

Molecular Weight

435.58

References & Citations

[1]Bergman JA, et al. S-Farnesyl-Thiopropionic Acid (FTPA) Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase. ACS Med Chem Lett. 2012 Jan 12;3 (1) :15-19.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-149709/ICMT-IN-35-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-149709/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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