ICMT-IN-21
Product Specifications
UNSPSC Description
ICMT-IN-21 (compound 6ag) is an ICMT inhibitor (IC50=8.8 μM), a sulfonamide-modified farnesyl cysteine (SMFC). The farnesyl and carboxylic acid motifs of ICMT-IN-21 are important structures for inhibiting ICMT[1].
Target Antigen
ICMT
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/icmt-in-21.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=CS1)(N[C@H](C(O)=O)CSC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=O
Molecular Weight
471.70
References & Citations
[1]Majmudar JD, et al. Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors. Bioorg Med Chem Lett. 2011 May 1;21(9):2616-20.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149707/ICMT-IN-21-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149707/
Clinical Information
No Development Reported
CAS Number
1310740-69-2
Curated Selection
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