ICMT-IN-21

ICMT-IN-21 (compound 6ag) is an ICMT inhibitor (IC50=8.8 μM), a sulfonamide-modified farnesyl cysteine (SMFC) . The farnesyl and carboxylic acid motifs of ICMT-IN-21 are important structures for inhibiting ICMT[1].

Product Specifications

CAS Number

[1310740-69-2]

UNSPSC

12352005

Target

ICMT

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/icmt-in-21.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=CS1)(N[C@H](C(O)=O)CSC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=O

Molecular Formula

C22H33NO4S3

Molecular Weight

471.70

References & Citations

[1]Majmudar JD, et al. Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors. Bioorg Med Chem Lett. 2011 May 1;21 (9) :2616-20.