ICMT-IN-7
ICMT-IN-7 (compound 74) is an inhibitor of ICMT (IC50=0.015 μM) . ICMT-IN-7 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras[1].
Product Specifications
CAS Number
1313603-21-2
UNSPSC
12352005
Target
ICMT
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/icmt-in-7.html
Solubility
10 mM in DMSO
Smiles
CC(C1)(C)OC(C)(C)CC1(CCNC2=CC=CC=C2)C3=CC=CC=C3
Molecular Formula
C23H31NO
Molecular Weight
337.50
References & Citations
[1]Judd WR, et al. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT) . J Med Chem. 2011 Jul 28;54 (14) :5031-47.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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