ICMT-IN-7

ICMT-IN-7 (compound 74) is an inhibitor of ICMT (IC50=0.015 μM) . ICMT-IN-7 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras[1].

Product Specifications

CAS Number

[1313603-21-2]

UNSPSC

12352005

Target

ICMT

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/icmt-in-7.html

Solubility

10 mM in DMSO

Smiles

CC(C1)(C)OC(C)(C)CC1(CCNC2=CC=CC=C2)C3=CC=CC=C3

Molecular Formula

C23H31NO

Molecular Weight

337.50

References & Citations

[1]Judd WR, et al. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT) . J Med Chem. 2011 Jul 28;54 (14) :5031-47.