M1/M2/M4 muscarinic agonist 1
M1/M2/M4 muscarinic agonist 1 (Compound 42) is a muscarinic M4/M1/M2 agonist with EC50 values of 6.5, 26 and 210 nM for M4/M1/M2, respectively. M1/M2/M4 muscarinic agonist 1 can be used for research on mental diseases, such as schizophrenia, delusion, etc[1].
Product Specifications
CAS Number
2640109-42-6
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/m1-m2-m4-muscarinic-agonist-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CC2(C[C@H](N3CCC(C4=CC=CC=C4OCC)CC3)CC2)C1)C5COC5
Molecular Formula
C24H34N2O3
Molecular Weight
398.54
References & Citations
[1]Christopher G Thomson, et al. Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists. ACS Med. Chem. Lett. 2023. Nov 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR1; mAChR2; mAChR4
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