ROCK2-IN-7
ROCK2-IN-7 is a kinase inhibitor targeting to ROCK2. ROCK2-IN-7 inhibits ROCK2/pSTAT3 Signaling. ROCK2-IN-7 suppresses systemic immunity activation and attenuates inflammation in psoriasis model[1].
Product Specifications
CAS Number
3000541-95-4
UNSPSC
12352005
Target
MMP; ROCK; STAT
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rock2-in-7.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C=C(C(C)=C1)F)C2=CC(CN[C@H]3CCC[C@@H](C3)NC4=CC=C5NN=CC5=C4)=CC=C2
Molecular Formula
C26H28FN5O
Molecular Weight
445.53
References & Citations
[1]Huang, Yun, et al. "Design, Synthesis, and Biological Evaluation of an Orally Bioavailable, Potent, and Selective ROCK2 Inhibitor for Psoriasis Treatment." Journal of Medicinal Chemistry (2023)
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-2; ROCK2; STAT3
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