EGFR-IN-91
EGFR-IN-91 (compound 9) is an orally available EGFR inhibitor with blood-brain barrier penetrability. EGFR-IN-91 inhibits EGFRL858R/C797S and EGFRexon 19del/C797S, inducing tumor regression in xenograft (PDX) mouse models. EGFR-IN-91 has the potential to inhibit localized and metastatic non-small cell lung cancer (NSCLC) driven by EGFR mutants[1].
Product Specifications
CAS Number
3032113-20-2
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-91.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(OCCOC2=C(OC)C=C3N=CN=C(NC4=CC=CC(Cl)=C4F)C3=C2)CC1
Molecular Formula
C22H25ClFN5O3
Molecular Weight
461.92
References & Citations
[1]Hill J et al. Discovery of a Hydroxylamine-Based Brain-Penetrant EGFR Inhibitor for Metastatic Non-Small-Cell Lung Cancer[J]. Journal of Medicinal Chemistry, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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