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VEGFR-2/c-Met-IN-2

VEGFR-2/c-Met-IN-2 (compound 3e) is a VEGFR-2/c-Met inhibitor, with IC50 values of 83 and 48 nM, respectively. VEGFR-2/c-Met-IN-2 exhibits cytotoxic activity against HCT-116 cell line (IC50: 3.403 µM) [1].

Product Specifications

CAS Number

[3017162-04-5]

UNSPSC

12352005

Target

C-Met/HGFR; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-2-c-met-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(NC(NC1=CC=C(Cl)C=C1)=S)C2=CC=C(N3C(NC4=C(C=CC=C4)C3=O)=O)C=C2

Molecular Formula

C22H15ClN4O3S

Molecular Weight

450.90

References & Citations

[1]Hassan A, et al. Novel 3-phenylquinazolin-2,4 (1H,3H) -diones as dual VEGFR-2/c-Met-TK inhibitors: design, synthesis, and biological evaluation. Sci Rep. 2023 Oct 30;13 (1) :18567.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Met; VEGFR2/KDR/Flk-1

Curated Selection

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