VEGFR-2/c-Met-IN-1
VEGFR-2/c-Met-IN-1 is a dual inhibitoe of VEGFR-2 and c-Met with IC50s of 138 nM and 74 nM, respectively. VEGFR-2/c-Met-IN-1 has antitumor activity[1].
Product Specifications
CAS Number
3017162-02-3
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-c-met-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=CC=C(NC(NC(C2=CC=C(N3C(NC4=C(C=CC=C4)C3=O)=O)C=C2)=O)=S)C=C1
Molecular Formula
C23H16N4O5S
Molecular Weight
460.46
References & Citations
[1]Abdelfattah Hassan, et al. Novel 3-phenylquinazolin-2,4 (1H,3H) -diones as dual VEGFR-2/c-Met-TK inhibitors: design, synthesis, and biological evaluation.Sci Rep. 2023 Oct 30;13 (1) :18567.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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