HSP70/SIRT2-IN-2
Product Specifications
UNSPSC Description
HSP70/SIRT2-IN-2 (Compounds 1a) is a dual inhibitor for SIRT2 and HSP70, with IC50 of 45.1±5.0 μM for SIRT2. HSP70/SIRT2-IN-2 has antitumor activity[1].
Target Antigen
HSP; Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/hsp70-sirt2-in-2.html
Solubility
10 mM in DMSO
Smiles
CSC1=CC(NC2=NC(C3=NC4=C(S3)C=CC=C4)=CS2)=CC=C1
Molecular Weight
355.50
References & Citations
[1]Elena Abbotto, et al. Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays. Pharmaceuticals (Basel). 2023 Sep 18;16(9):1316.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149638/HSP70-SIRT2-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149638/
Clinical Information
No Development Reported
CAS Number
1796557-72-6
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