HSP70/SIRT2-IN-2

HSP70/SIRT2-IN-2 (Compounds 1a) is a dual inhibitor for SIRT2 and HSP70, with IC50 of 45.1±5.0 μM for SIRT2. HSP70/SIRT2-IN-2 has antitumor activity[1].

Product Specifications

CAS Number

[1796557-72-6]

UNSPSC

12352005

Target

HSP; Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hsp70-sirt2-in-2.html

Solubility

10 mM in DMSO

Smiles

CSC1=CC(NC2=NC(C3=NC4=C(S3)C=CC=C4)=CS2)=CC=C1

Molecular Formula

C17H13N3S3

Molecular Weight

355.50

References & Citations

[1]Elena Abbotto, et al. Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays. Pharmaceuticals (Basel) . 2023 Sep 18;16 (9) :1316.