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HSP70/SIRT2-IN-1

HSP70/SIRT2-IN-1 (Compounds 2a) is a dual inhibitor for SIRT2 and HSP70, with IC50 of 17.3±2.0 μM for SIRT2. HSP70/SIRT2-IN-1 has antitumor activity[1].

Product Specifications

UNSPSC

12352005

Target

HSP; Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hsp70-sirt2-in-1.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(C2=CSC(NC3=CC(SC)=C(CC)C=C3)=N2)C=C1

Molecular Formula

C18H17ClN2S2

Molecular Weight

360.92

References & Citations

[1]Elena Abbotto, et al. Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays. Pharmaceuticals (Basel) . 2023 Sep 18;16 (9) :1316.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HSP70; SIRT2

Frequently Asked Questions

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