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EGFR/HER2/DHFR-IN-2

EGFR/HER2/DHFR-IN-2 (Compound 4b) is an inhibitor of EGFR, HER2, and DHFR (IC50: 0.248, 0.156, 0.138 μM respectively) . EGFR/HER2/DHFR-IN-2 has anticancer activities against a panel of cancer cells (IC50: 9.14, 7.33, 14.18, 24.87, 20.07, 6.16 μM for Hep G2, HeLa, HEp-2, HCT 116, PC-3, MCF7 cells) . EGFR/HER2/DHFR-IN-2 reduce breast cancer tumor growth[1].

Product Specifications

UNSPSC

12352005

Target

Dihydrofolate reductase (DHFR) ; EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-her2-dhfr-in-2.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(OCCC)N=C(C2=CC=C(C)C=C2)C=C1C3=CC=C(Br)C=C3

Molecular Formula

C22H19BrN2O

Molecular Weight

407.30

References & Citations

[1]Hawas SS, et al. New 2-alkoxycyanopyridine derivatives as inhibitors of EGFR, HER2, and DHFR: Synthesis, anticancer evaluation, and molecular modeling studies. Bioorg Chem. 2023 Sep 21;141:106874.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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