EGFR/HER2/DHFR-IN-2
EGFR/HER2/DHFR-IN-2 (Compound 4b) is an inhibitor of EGFR, HER2, and DHFR (IC50: 0.248, 0.156, 0.138 μM respectively) . EGFR/HER2/DHFR-IN-2 has anticancer activities against a panel of cancer cells (IC50: 9.14, 7.33, 14.18, 24.87, 20.07, 6.16 μM for Hep G2, HeLa, HEp-2, HCT 116, PC-3, MCF7 cells) . EGFR/HER2/DHFR-IN-2 reduce breast cancer tumor growth[1].
Product Specifications
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR) ; EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-her2-dhfr-in-2.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(OCCC)N=C(C2=CC=C(C)C=C2)C=C1C3=CC=C(Br)C=C3
Molecular Formula
C22H19BrN2O
Molecular Weight
407.30
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog