CYP51/PD-L1-IN-4
CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target (CYP51/PD-L1) inhibitor, with IC50 values of 0.17 and 0.021 μM, respectively. CYP51/PD-L1-IN-4 exhibits excellent antifungal and antidrug-resistant fungal activity in vitro. CYP51/PD-L1-IN-4 can be used for fungal infections research[1].
Product Specifications
CAS Number
3032391-34-4
UNSPSC
12352005
Target
Cytochrome P450; PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cyp51-pd-l1-in-4.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C2=CC=CC=C2)C=CC=C1COC3=CC(CN[C@@H](C(OCC)=O)CN4C=NC=N4)=CC=C3
Molecular Formula
C28H30N4O3
Molecular Weight
470.56
References & Citations
[1]Liu Y, et al. Construction and Evaluation of Novel Dual-function Antifungal Inhibitors and Covalent Organic Framework Carriers Based on the Infection Microenvironment. J Med Chem. 2023 Oct 12;66 (19) :13838-13857.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP51
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