CYP51/PD-L1-IN-4

CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target (CYP51/PD-L1) inhibitor, with IC50 values of 0.17 and 0.021 μM, respectively. CYP51/PD-L1-IN-4 exhibits excellent antifungal and antidrug-resistant fungal activity in vitro. CYP51/PD-L1-IN-4 can be used for fungal infections research[1].

Product Specifications

CAS Number

[3032391-34-4]

UNSPSC

12352005

Target

Cytochrome P450; PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cyp51-pd-l1-in-4.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C2=CC=CC=C2)C=CC=C1COC3=CC(CN[C@@H](C(OCC)=O)CN4C=NC=N4)=CC=C3

Molecular Formula

C28H30N4O3

Molecular Weight

470.56

References & Citations

[1]Liu Y, et al. Construction and Evaluation of Novel Dual-function Antifungal Inhibitors and Covalent Organic Framework Carriers Based on the Infection Microenvironment. J Med Chem. 2023 Oct 12;66 (19) :13838-13857.