Nurr1 agonist 5

Nurr1 agonist 5 (compound 5o) is a neuroprotective transcription factor Nurr1 agonist with a Kd of 0.5 μM and an EC50 of 3 μM[1].

Product Specifications

CAS Number

[3033875-32-7]

UNSPSC

12352005

Target

Nuclear Hormone Receptor 4A/NR4A

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nurr1-agonist-5.html

Solubility

10 mM in DMSO

Smiles

ClC1=C(C=C2C(C=CN2)=C1)C(NC3=C(C=CC(Cl)=C3)OCCN(C)C)=O

Molecular Formula

C19H19Cl2N3O2

Molecular Weight

392.28

References & Citations

[1]Minh Sai, et al. Structure-Guided Design of Nurr1 Agonists Derived from the Natural Ligand Dihydroxyindole. J Med Chem. 2023 Oct 12;66 (19) :13556-13567.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Nurr1/NR4A2

Curated Selection

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