Nurr1 agonist 5
Nurr1 agonist 5 (compound 5o) is a neuroprotective transcription factor Nurr1 agonist with a Kd of 0.5 μM and an EC50 of 3 μM[1].
Product Specifications
CAS Number
[3033875-32-7]
UNSPSC
12352005
Target
Nuclear Hormone Receptor 4A/NR4A
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nurr1-agonist-5.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(C=C2C(C=CN2)=C1)C(NC3=C(C=CC(Cl)=C3)OCCN(C)C)=O
Molecular Formula
C19H19Cl2N3O2
Molecular Weight
392.28
References & Citations
[1]Minh Sai, et al. Structure-Guided Design of Nurr1 Agonists Derived from the Natural Ligand Dihydroxyindole. J Med Chem. 2023 Oct 12;66 (19) :13556-13567.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nurr1/NR4A2
Curated Selection
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