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KHK-IN-4

KHK-IN-4 (compound 14) is a potent ketohexokinase (KHK) inhibitor. KHK-IN-4 can be used for fructose metabolic disease research[1].

Product Specifications

CAS Number

3034829-40-5

UNSPSC

12352005

Target

Ketohexokinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/khk-in-4.html

Solubility

10 mM in DMSO

Smiles

C[C@H]1CCN1C2=NC(N3CC[C@@H](C3)CCC(O)=O)=C4C(C(F)(CC4)F)=N2

Molecular Formula

C18H24F2N4O2

Molecular Weight

366.41

References & Citations

[1]Guodong Zhu, et al. Discovery of a Novel Ketohexokinase Inhibitor with Improved Drug Distribution in Target Tissue for the Treatment of Fructose Metabolic Disease. J Med Chem. 2023 Oct 12;66 (19) :13501-13515.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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