Aβ-IN-7

Aβ-IN-7 (compound 5a) is a potent inhibitor of the Aβ aggregation. Aβ-IN-7 with 50 μM stabilize Aβ monomers in the small oligomeric species and prolong the nucleation process. Aβ-IN-7 inhibits Aβ fibril formation better than Aβ-IN-8 (HY-149583) in 50 μM[1].

Product Specifications

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/aβ-in-7.html

Solubility

10 mM in DMSO

Smiles

C1(/C=N/C2=NC3=CC=CC=C3S2)=CC=CC=C1

Molecular Formula

C14H10N2S

Molecular Weight

238.31

References & Citations

[1]Mohammad Hossein Asgarshamsi, et al. Synthesis of Some Benzothiazole Derivatives Based on 3-Hydroxypyridine-4-one and Benzaldehyde and Evaluation of Their β-Amyloid Aggregation Inhibition Using both Experimental Methods and Molecular Dynamic Simulation. Chem Biodivers. 2023 Sep 10:e202301113.