Aβ-IN-7
Aβ-IN-7 (compound 5a) is a potent inhibitor of the Aβ aggregation. Aβ-IN-7 with 50 μM stabilize Aβ monomers in the small oligomeric species and prolong the nucleation process. Aβ-IN-7 inhibits Aβ fibril formation better than Aβ-IN-8 (HY-149583) in 50 μM[1].
Product Specifications
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aβ-in-7.html
Solubility
10 mM in DMSO
Smiles
C1(/C=N/C2=NC3=CC=CC=C3S2)=CC=CC=C1
Molecular Formula
C14H10N2S
Molecular Weight
238.31
References & Citations
[1]Mohammad Hossein Asgarshamsi, et al. Synthesis of Some Benzothiazole Derivatives Based on 3-Hydroxypyridine-4-one and Benzaldehyde and Evaluation of Their β-Amyloid Aggregation Inhibition Using both Experimental Methods and Molecular Dynamic Simulation. Chem Biodivers. 2023 Sep 10:e202301113.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149582/Aβ-IN-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149582/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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