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NF-κB-IN-12

NF-κB-IN-12 (compound 3h) is a potent NF-κB inhibitor, with an IC50 of 1.02 μM. NF-κB-IN-12 can be used for acute lung injury research[1].

Product Specifications

UNSPSC

12352005

Target

NF-κB

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nf-κb-in-12.html

Solubility

10 mM in DMSO

Smiles

O=C(N1N=CC(C2=CC=C(S(=O)(C3=CC=C(O)C=C3)=O)C=C2)C1C4=CC=C(OC)C=C4)C5=CN6C(C(NC)=NC=C6)=N5

Molecular Formula

C30H26N6O5S

Molecular Weight

582.63

References & Citations

[1]Zang B, et al. Synthesis and protective effect of pyrazole conjugated imidazo[1,2-a]pyrazine derivatives against acute lung injury in sepsis rats via attenuation of NF-κB, oxidative stress, and apoptosis. Acta Pharm. 2023 Sep 14;73 (3) :341-362.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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