α-Glucosidase-IN-36

α-Glucosidase-IN-36 (compound 5g) is a potent α-glucosidase inhibitor, with an IC50 of 6.69 ± 0.18 μM, Ki and Kis of 1.65 μM and 4.54 μM, respectively. α-Glucosidase-IN-36 may inhibit α-glucosidase activity by binding with its active site as well as changing the secondary structure of α-glucosidase. α-Glucosidase-IN-36 can be used for type 2 diabetes mellitus (T2DM) research[1].

Product Specifications

CAS Number

[3025234-94-7]

UNSPSC

12352005

Target

Glycosidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/α-glucosidase-in-36.html

Solubility

10 mM in DMSO

Smiles

BrC1=CC=C(/C=N/N2C(COC3=CC=CC=C3)=NN=C2SCC(NC4=CC=C(OCC)C=C4)=O)C=C1

Molecular Formula

C26H24BrN5O3S

Molecular Weight

566.47

References & Citations

[1]Luo S, et al. Design, synthesis, biological evaluation, and docking study of new triazole-phenylacetamide derivatives as α-glucosidase inhibitors. Bioorg Chem. 2023 Sep 6;141:106844.