Thalidomide-4-O-C13-NH2 (hydrochloride)
Thalidomide-4-O-C13-NH2 hydrochloride is the Thalidomide (HY-10984) -based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C13-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-4-o-c13-nh2-hydrochloride.html
Purity
99.75
Solubility
10 mM in DMSO
Smiles
O=C(N1C2C(NC(CC2)=O)=O)C(C(OCCCCCCCCCCCCCN)=CC=C3)=C3C1=O.Cl
Molecular Formula
C26H38ClN3O5
Molecular Weight
508.05
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
AKT3 (RAC-gamma Serine/Threonine-protein Kinase, Protein Kinase Akt-3, Protein Kinase B gamma, PKB gamma, RAC-PK-gamma, STK-2, PKBG) (MaxLight 550)
