CXCR4-IN-2
CXCR4-IN-2 (compound A1) is a bifunctional fluorinated small molecule that is a potent CXCR4 inhibitor with anticancer activity. CXCR4-IN-2 has cytotoxic (IC50: 60 μg/mL; 72 h) and antiproliferative effects on mouse colorectal cancer (CRC) cells. CXCR4-IN-2 induces cell arrest in the G2/M phase and induces apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; CXCR
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cxcr4-in-2.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(/N=C(NC(N/C(C(F)(F)F)=N/C2=CC(C)=C(C)C=C2)=S)\C(F)(F)F)C=C1C
Molecular Formula
C21H20F6N4S
Molecular Weight
474.47
References & Citations
[1]Khorramdelazad H, et al. Antitumor activities of a novel fluorinated small molecule (A1) in CT26 colorectal cancer cells: molecular docking and in vitro studies. J Biomol Struct Dyn. 2023 Sep 13:1-14.. .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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