GSK-3β inhibitor 15
GSK-3β inhibitor 15 (Compound 54) is a GSK-3β inhibitor (IC50: 3.4 nM) . GSK-3β inhibitor 15 inhibits Aβ1-42-induced GSK-3β and tau protein phosphorylation. GSK-3β inhibitor 15 inhibits LPS-induced iNOS expression. GSK-3β inhibitor 15 has neuroprotective effects on Aβ1-42-induced neurotoxicity. GSK-3β inhibitor 15 can be used for research of Alzheimer’s disease (AD) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; GSK-3; Tau Protein
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gsk-3β-inhibitor-15.html
Solubility
10 mM in DMSO
Smiles
O=C(CCN1N=CC(C)=C1)NC2=NNC3=C2SC(C4=CN=CC=C4)=C3
Molecular Formula
C17H16N6OS
Molecular Weight
352.41
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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