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DNA Gyrase-IN-9

DNA Gyrase-IN-9 (compound 4j) is an antibacterial agent that targets DNA gyrase. The MIC to inhibit Gram bacteria is 0.5-2 μg/mL, and the MBC to kill Gram bacteria is 2-8 μg/mL. DNA Gyrase-IN-9 inhibits DNA gyrase in Staphylococcus aureus with IC50=6.29 μg/mL[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dna-gyrase-in-9.html

Solubility

10 mM in DMSO

Smiles

N#CC(C1C2=CC=C(C3=CC=CC=C3)C=C2)=C(O)OC4=C1C(C)=NN4C5=CC=C(Cl)C=C5

Molecular Formula

C26H18ClN3O2

Molecular Weight

439.89

References & Citations

[1]Almaghrabi M, et al. Introducing of novel class of pyrano [2, 3-c] pyrazole-5-carbonitrile analogs with potent antimicrobial activity, DNA gyrase inhibition, and prominent pharmacokinetic and CNS toxicity profiles supported by molecular dynamic simulation[J]. Journal of Biomolecular Structure and Dynamics, 2023: 1-18.. . .

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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